Despite the warnings of her friends at Mount Olympus Academy, Persephone befriends bad-boy Hades, but following her mother's advice to "go along to get along" complicates her relationships with all of them.
For an extra credit project, Aphrodite begins a club for matchmaking mortals, which brings her to Egypt and face-to-face with her competition, the Egyptian goddess Isis.
Seeking to become immortal like the other Goddess Girls, Medusa searches for a magical necklace, an effort that is compromised by her mean reputation, her snaky hair, and unexpected consequences.
In order to fit in at Mount Olympus Academy, new girl and forest-mountain nymph Echo copies the mannerisms of all the other students, but instead of ingratiating herself to her classmates, it only seems to grate on them.
When Orpheus, a charming mortal musician, arrives at Mount Olympus Academy, he asks Persephone to help reunite him with his lost love, Eurydice, but trying to manipulate the rules of the underworld puts her at odds with her boyfriend, Hades.