When a former member of NERDS turns into a villainous cheerleader, Matilda "Wheezer" Choi and the rest of the NERDS must infiltrate the cheerleader squad and save the world from a machine that wreaks havoc by entering other dimensions.
Led by Duncan "Gluestick" Dewey, the NERDS team uses brain power and courage rather than gadgets when they face off against supervillian Simon, his band of savage squirrels, and Albert, a middle-aged computer genius who lives with his mother.
While running a spy network from their elementary school, five unpopular misfits combine their enhanced abilities and use cutting-edge gadgetry to fight evil around the world.