When a virus infects Arlington, Virginia, home of NERDS headquarters, transforming victims into criminal masterminds, it is up to Flinch to stop its spread by miniaturizing himself and entering the head of the Villain Virus's creator, Heathcliff Hodges.
When Ms. Information kidnaps the President's daughter, it is up to twelve-year-old Ruby, also known as Pufferfish, to use her super-nanobyte-enhanced allergies in leading the NERDS' investigation.