Seventeen-year-old Greg has managed to become part of every social group at his Pittsburgh high school without having any friends, but his life changes when his mother forces him to befriend Rachel, a girl he once knew in Hebrew school who has leukemia.

After receiving a death threat on her personal cell phone, actress Mercedes Grant decides to escape to a remote cabin near Idaho's Snake River. While there handsome town physician Luke Parker, a fan of Mercedes, must give her a devstating and unexpected diagnosis. As Mercedes struggles to come to terms with her new future, she relies on Luke's support. But neither imagines the disease is not the only danger Mercedes is facing.