After years of standing by their women, the Sisterhood's significant others have also become loyal friends. And now Jack Emery, Nikki's husband, has enlisted Ted, Joe, Jay, Bert, Dennis, and Abner to form a top-secret organization known as BOLO Consultants.

A missing canister containing a deadly virus forms the center of a storm that traps Stanley Oxenford, director of a medical research firm, and a violent trio of thugs in a remote house during a Christmas Eve blizzard.